Intravenous Immunoglobulin for Management of Non-paraneoplastic Autoimmune Retinopathy

Purpose: To report a case of non-paraneoplastic autoimmune retinopathy (npAIR) treated with intravenous immunoglobulin (IVIG). Case report: A 12-year-old boy presented with progressive visual field loss, nyctalopia, and flashing for three months. He had suffered from common cold two weeks before the onset of these symptoms. On the basis of clinical history and paraclinical findings, he was diagnosed with npAIR, and IVIG without immunosuppressive therapy was started. During the one-year follow-up period after the first course of IVIG, flashing disappeared completely. Visual acuity remained 10/10, but nyctalopia did not improve. Multimodal imaging showed no disease progression. Conclusion: Although established retinal degenerative changes seem irreversible in npAIR, IVIG may be a suitable choice to control the disease progression

Finasteride induced depression: a prospective study

BACKGROUND: Finasteride is a competitive inhibitor of 5 alpha-reductase enzyme, and is used for treatment of benign prostatic hyperplasia and androgenetic alopecia. Animal studies have shown that finasteride might induce behavioral changes. Additionally, some cases of finasteride-induced depression have been reported in humans. The purpose of this study was to examine whether depressive symptoms or anxiety might be induced by finasteride administration. METHODS: One hundred and twenty eight men with androgenetic alopecia, who were prescribed finasteride (1 mg/day) were enrolled in this study. Information on depressed mood and anxiety was obtained by Beck Depression Inventory (BDI), and Hospital Anxiety and Depression Scale (HADS). Participants completed BDI and HADS questionnaires before beginning the treatment and also two months after it. RESULTS: Mean age of the subjects was 25.8(± 4.4) years. At baseline, mean BDI and HADS depression scores were 12.11(± 7.50) and 4.04(± 2.51), respectively. Finasteride treatment increased both BDI (p < 0.001) and HADS depression scores significantly (p = 0.005). HADS anxiety scores were increased, but the difference was not significant (p = 0.061). CONCLUSION: This preliminary study suggests that finasteride might induce depressive symptoms; therefore this medication should be prescribed cautiously for patients with high risk of depression. It seems that further studies would be necessary to determine behavioral effects of this medication in higher doses and in more susceptible patients

CHAD: Charlotte Anomaly Dataset

In recent years, we have seen a significant interest in data-driven deep learning approaches for video anomaly detection, where an algorithm must determine if specific frames of a video contain abnormal behaviors. However, video anomaly detection is particularly context-specific, and the availability of representative datasets heavily limits real-world accuracy. Additionally, the metrics currently reported by most state-of-the-art methods often do not reflect how well the model will perform in real-world scenarios. In this article, we present the Charlotte Anomaly Dataset (CHAD). CHAD is a high-resolution, multi-camera anomaly dataset in a commercial parking lot setting. In addition to frame-level anomaly labels, CHAD is the first anomaly dataset to include bounding box, identity, and pose annotations for each actor. This is especially beneficial for skeleton-based anomaly detection, which is useful for its lower computational demand in real-world settings. CHAD is also the first anomaly dataset to contain multiple views of the same scene. With four camera views and over 1.15 million frames, CHAD is the largest fully annotated anomaly detection dataset including person annotations, collected from continuous video streams from stationary cameras for smart video surveillance applications. To demonstrate the efficacy of CHAD for training and evaluation, we benchmark two state-of-the-art skeleton-based anomaly detection algorithms on CHAD and provide comprehensive analysis, including both quantitative results and qualitative examination. The dataset is available at https://github.com/TeCSAR-UNCC/CHAD

Understanding Ethics, Privacy, and Regulations in Smart Video Surveillance for Public Safety

Recently, Smart Video Surveillance (SVS) systems have been receiving more attention among scholars and developers as a substitute for the current passive surveillance systems. These systems are used to make the policing and monitoring systems more efficient and improve public safety. However, the nature of these systems in monitoring the public's daily activities brings different ethical challenges. There are different approaches for addressing privacy issues in implementing the SVS. In this paper, we are focusing on the role of design considering ethical and privacy challenges in SVS. Reviewing four policy protection regulations that generate an overview of best practices for privacy protection, we argue that ethical and privacy concerns could be addressed through four lenses: algorithm, system, model, and data. As an case study, we describe our proposed system and illustrate how our system can create a baseline for designing a privacy perseverance system to deliver safety to society. We used several Artificial Intelligence algorithms, such as object detection, single and multi camera re-identification, action recognition, and anomaly detection, to provide a basic functional system. We also use cloud-native services to implement a smartphone application in order to deliver the outputs to the end users

Magnetic resonance imaging of intact globe superior subluxation into the intracranium

A 67-year-old man with right-sided blunt ocular trauma is reported here. Despite having received primary medical care, the patient complained of severe headache for 14 days. Initial computed tomography (CT) indicated hematoma in the right frontal lobe. However, magnetic resonance imaging (MRI) indicated that the right globe along with its optic nerve had been intactly dislocated into the intracranium and differentiated from hematoma. In this case, the significance of MRI, in blunt ocular trauma work-up, and also regaining successful ocular function are highlighted

Combined Aneurysms of the Main Renal and Celiac Arteries: An Unusual Association

Celiac artery aneurysm (CAA) is a rare condition, which occasionally occurs in association with such visceral aneurysms as splenic, common hepatic, left hepatic, supe-rior mesenteric and renal arteries. We describe our observation of a patient with CAA and bilateral main renal artery aneurysm. To the best of our knowledge, a combination of these visceral arterial aneurysms has not been reported previously. The available literature on this topic is briefly reviewed

Osteoprotegerin and Soluble Receptor Activator of Nuclear Factor-Kappa B Ligand in Exudative Age-Related Macular Degeneration

Calcification and inflammation are among the important cases of exudative age-related macular degeneration (E-ARMD). The aim of the present study was to elucidate if there is any relationship between serum Osteoprotegerin (OPG), soluble receptor activator of nuclear factor-kappa B ligand (RANK-ligand) and E-ARMD. In a cross-sectional study, we compared 45 E-ARMD patients with 45 matched controls. Diagnosis was confirmed by fluorescein angiography. Serum samples were analyzed for OPG, RANK-ligand, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and triglyceride (TG). The levels of OPG and RANK-ligand were measured by ELISA methods. The mean age was 72.0±11.5 years in the E-ARMD group and 68.2±8.9 years in the control group (p=0.09). The level of serum OPG was 132.10±75.49 pg/ml in the E-ARMD group and 94.88±61.65 pg/ml in the control subjects. E-ARMD patients had significantly high levels of OPG (p=0.012), as well as significantly high levels of LDL-C and TC (p=0.001 and p=0.005, respectively). We could not find any significant difference in RANK-ligand, HDL-C, or TG between two study groups (p>0.05). To the best of our knowledge, this is the first study investigating the levels of OPG in E-ARMD patients. The present study showed that E-ARMD patients had high levels of serum OPG. It may act as a protective factor for E-ARMD or only as a secondary phenomenon of different processes of E-ARMD. Further prospective studies would be necessary for prognostic and predictive significance of OPG in patients affected by E-ARMD

Asymptomatic Bilateral Ureteropelvic Junction Obstruction due to Supernumerary Renal Arteries

A supernumerary renal artery is a common arterial variation, which warrants consi-derations in a variety of urologic and retroperitoneal operations. Supernumerary renal arteries can be associated with other uro-vascular variations and anomalies such as duplicated renal veins and ureters, aberrant origin of the gonadal arteries, persistence of fetal renal lobulation, and kidney malrotation. The role of crossing supernumerary renal arteries in ureteropelvic junction obstruc-tion (UPJO) is controversial. We report a healthy potential renal transplant donor with bilateral UPJO, which appeared to be secondary to supernumerary renal (inferior polar) arteries. We believe that the bilateral occurrence of asymptomatic UPJO associated with supernumerary renal arteries has not been previously reported